Human genetics: how genes contribute to health and diseases, including cancer. The strength of this integrated approach is that students who complete the book will have a strong command of genetics as it is practiced today by both academic and corporate researchers.
These scientists are rapidly changing our understanding of living organisms, including ourselves. Modern genetics is a molecular-level science, but an understanding of its origins and the discovery of its principles isa necessary context. From the outset, however, we aim to integrate organism-level genetics with fundamental molecular mechanisms. Chapter 1 presents the foundation of this integration by summarizing the main biological themes we explore.
In the same chapter, we point to the relatedness of the patterns of heredity in all organisms. Starting in Chapter 6, we focus on the physical characteristics of DNA, on mutations, and on how DNA encodes, copies, and transmits biological information.
Beginning in Chapter 9, we move into the digital revolution in DNA analysis with a look at modern genetics techniques, including gene cloning, PCR, microarrays, and high-throughput genome sequencing. We explore how bioinformatics, an emergent analytical tool, can aid in discovery of genome features. This section concludes in Chapter 11 with case studies leading to the discovery of human disease genes. Chapter 19 describes the use of genetic tools at the molecular level to uncover the complex interactions of eukaryotic development.
Holland Adaptation in Natural and Artificial Systems. University of Michigan Press. Mitchell , S. Freeman has published by the Griffiths author team, implements an innovative approach to teaching genetics.
Genetics : Analysis of genes and genomes. Hayes, C. Cantorna, and H. Vitamin D and multiple sclerosis. Proc Soc Exp Biol Med 1 : 21— Brooker , R. Genetics : Analysis and Principles. New York : McGraw - Hill. New York : W. Microbiology , 5th ed. Hammond, J. Description of Genomes 4th Edition Genomes 4th edition written by T. Brown is a great book for Genetics related studies available in ebook PDF to get a printable download.
There have been remarkable advances in our knowledge of genomes since the previous edition of this book was published ten years ago. Back in , next-generation sequencing was in its infancy and high-throughput meth-ods for transcriptomics and proteomics were only beginning to be exploited. The application of these methods over the last ten years has resulted in an exponential increase in the number of species for which genome sequences and annotations are now available and single species to be examined by multiple versions of the genome.
The profusion of new sequences has had a particularly dramatic impact on bacterial genomics, with the introduction of the pan-genome concept and the discovery of extensive lateral transfer of genes between species.
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